The 1921 Wiley Wildcats football team was an American football team that represented Wiley College during the 1921 college football season. The Wiley team met Talladega in a post-season game on December 9 to determine the black college football national championship; the game ended in a 7–7 tie and both teams are recognized as co-champions. The Wiley team played its home games at the 1,000-seat Wiley Athletic Park in Marshall, Texas.
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